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                                    Avalyn is a biopharma company committed to developing improved therapies for the treatment of idiopathic pulmonary fibrosis (IPF) and other severe respiratory diseases. Our lead asset is inhaled pirfenidone (AP01) for the treatment of IPF. With offices in Seattle and San Diego, Avalyn's experienced clinical and inhaled product development team is rapidly advancing AP01 for the treatment of IPF and additional pipeline candidates for IPF and other severe respiratory diseases.

                                    Corporate Fact Sheet

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                                    Similar to a scar obtained from an injury to the skin, pulmonary fibrosis (PF) is a scar that forms in the lungs. However, pulmonary fibrosis has much more serious consequences than a simple scar. In PF, scar tissue builds up in the scaffolding of the lungs and makes it difficult for inhaled oxygen to enter the blood. Low oxygen levels and lung stiffness from the formed scar cause a person to feel short of breath reducing their ability to exercise or perform normal daily activities. Idiopathic pulmonary fibrosis (IPF) is severe form of PF, where in the absence of lung transplant, the majority of patients only survive 2-5 years. Comparatively, IPF causes more deaths per year than breast cancer and only lung cancer has a worse prognosis. IPF primarily affects people over the age of 50 and is more common in men than women.

                                    With about 46,000 people diagnosed each year and between 120,000 and 150,000 living in each region, IPF is recognized as an orphan indication by both US and European regulatory agencies.

                                    IPF treatments are relatively new, with the first and only approvals coming in 2014; oral pirfenidone (Esbriet®) and oral nintedanib (Ofev®). Each medicine, while effective, is associated with significant adverse effects that limit dosing and their full potential for efficacy. While these medicines are an important first step to treat IPF, a substantial unmet need remains for highly tolerable medicines enabling improved effects as stand-alone and add-on combination therapies.

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                                    Small inhaled doses deliver highly-effective lung levels while avoiding side effects associated with large oral doses.

                                    Pirfenidone is a low potency drug that requires a very large oral dose to deliver highly-effective lung levels. Unfortunately, blood level safety limits and poor compliance due to oral dose related adverse effects reduce the oral product's benefit. To maximize pirfenidone's potential, Avalyn has reformulated pirfenidone for nebulization and inhaled aerosol lung delivery. By this approach, small inhaled doses delivered directly to the lung hold promise to maximize pirfenidone's effect while avoiding adverse effects associated with oral delivery.

                                    Our data indicates that as stand-alone therapy, inhalation may substantially-reduce or eliminate oral adverse effects and potentially increase pirfenidone's efficacy through a greater lung dose and improved compliance. Moreover, as a safe and well-tolerated therapy, inhalation may enable pirfenidone's use in otherwise poorly-tolerated, add-on combination regimens.

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                                    A. Bruce Montgomery, MD Chief Executive Officer
                                    Mark Surber, PhD acgp加速器
                                    Nancy McKinley Vice President, Finance
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                                    Stephen Pham, PhD Vice President, Product Development

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                                    A. Bruce Montgomery, MD Chief Executive Officer
                                    Jonathan Leff, MD Independent Director
                                    Ketan Patel, MD F-Prime Capital
                                    Sofia Ioannidou, PhD acgp加速器
                                    Tiba Aynechi, PhD Novo A/S
                                    Niall O'Donnell, PhD RiverVest Venture Partners
                                    Heather Preston, MD acgp加速器
                                    Robert Mittendorff, MD Norwest Venture Partners
                                    Mark Surber, PhD Chief Scientific Officer, Observer

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                                    April 27, 2024 Avalyn Pharma Secures $35.5 Million Series B Financing, Broadens Development Portfolioacgp加速器 IPF up and comers look to add on rather than competeApril 21, 2014 实战Linux服务器安全加固培训视频教程_屌丝建站教程自学网:2021-9-5 · 本套实战Linux服务器安全加固培训视频教程是一套非常不错的视频自学教学,对您的linux安全维护水平应该会有相当的一部分提高,学习贵在坚持,屌丝建站教程自学网祝您在学习的道路
                                    acgp加速器 Aerosol Pirfenidone Pharmacokinetics after Inhaled Delivery in Sheep: a Viable Approach to Treating Idiopathic Pulmonary FibrosisSeptember 3, 2014 Will little-known company's inhaled candidate take down InterMune-Roche's pirfenidone?June 5, 2013 Genoa Pharmaceuticals and McMaster University demonstrate in vivo benefit of inhaled pirfenidone offering greater pulmonary fibrosis efficacy than oral therapy
                                    acgp加速器 A Randomized Double-Blind Placebo-Controlled Dose-Escalation Phase 1 Study of Aerosolized Pirfenidone...August 5, 2014 Genoa Pharmaceuticals Receives Orphan-Drug Designation for Pirfenidone in the Inhaled Treatment of Idiopathic Pulmonary Fibrosis (IPF)January 16, 2013 Genoa Pharmaceuticals and McMaster University to collaborate on Idiopathic Pulmonary Fibrosis Research
                                    May 15, 2017 Genoa Pharmaceuticals Secures $62 Million Series A Financing, Adds to Leadership TeamMay 13, 2014 Genoa Pharmaceuticals to Present at the Annual American Thoracic Society International Conference